Some authors have linked obesity in childhood with early adrenarche, i.e., increased circulating levels of adrenal androgens others have associated low levels in late life with increased frailty and all-cause mortality. During the last decades, several epidemiologic and cohort studies have shown the age-related circulating levels of DHEA/DHEAS these first increase in childhood, a process called “adrenarche”, peak in the 3 rd decade of life, and progressively decrease in midlife, a phenomenon called “adrenopause”. They are both precursor hormones that may be transformed into weak androgens or estrogens. Dehydroepiandrosterone (DHEA) and its metabolite DHEA sulfate (DHEAS), are steroid pre-hormones synthesized and secreted primarily by the zona reticularis of the adrenal cortex in response to adrenocorticotropic hormone (ACTH).
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